Automated Detection and Grading of Hip Osteoartritis

Start date: 01-01-2023
End date: 30-06-2023

Clinical problem

Osteartritis (OA) of the hip joint is a common condition which can lead to severe health problems. According to the RIVM, around 1.5 million people in the Netherlands suffer from OA (500 million worldwide), which is diagnosed using plain radiographs. On the radiographs, radiologists recognize OA by noticing joint space narrowing, extra bone formation (called ‘osteofytes’) and increased bone density. In a clinical setting, the number of radiographs that need OA screening is very high, and the interobserver reliability in grading the severity of OA is low to moderate.

Solution

In this project we plan to develop a deep learning algorithm for automated detection of joint space narrowing, extra bone formation and increased bone density. Besides automated detection, the algorithm must also be trained to grade hip OA severity with the Kellgren and Lawrence score. The algorithm will be externally validated in an orthopedic surgery department. We will build further on a previous deep learning algorithms developed for this purpose but which were developed with only smaller subsets of radiographs and with older deep learning algorithms.

Data

The World COACH consortium, a worldwide collaboration of 8 prospective cohorts on hip osteoarthritis include 40,555 participants (aged 35 to 80 years at baseline), of which 34,018 participants have annotated baseline pelvic radiographs available. This consortium is hosted by Erasmus MC and this project will therefore be carried out in close collaboration with Erasmus MC.

Results

When the algorithm has sufficient sensitivity and specificity it will be evaluated in practice.

People

Mar Navarro Padilla

Mar Navarro Padilla

Master Student

Diagnostic Image Analysis Group

Walter van der Weegen

Walter van der Weegen

Researcher

St. Anna Hospital

Rintje Agricola

Rintje Agricola

Orthopedic surgeon

St. Anna Hospital

Bram van Ginneken

Bram van Ginneken

Professor, Scientific Co-Director

Diagnostic Image Analysis Group

Matthieu Rutten

Matthieu Rutten

Associate Professor, Radiologist

Diagnostic Image Analysis Group

Silvan Quax

Silvan Quax

Head RTC Deep Learning

RTC Deep Learning